Despite their concomitant emergence in the 1990s, γ‐peptide foldamers have not developed
as fast as β‐peptide foldamers and to date, only a few γ‐oligomer structures have been …

The α, β‐unsaturated γ‐lactams have been found in many biologically active peptide natural
products. Due to their biological activities, extensive efforts have been made in the literature …

The impact of geometrically constrained cis α, β‐unsaturated γ‐amino acids on the folding of
α, γ‐hybrid peptides was investigated. Structure analysis in single crystals and in solution …

Nonribosomal E-vinylogous γ-amino acids are widely present in many peptide natural
products and have been exploited as inhibitors for serine and cysteine proteases. Here, we …

Synthesis, crystal conformations of α/γ4-hybrid peptide helices containing proteinogenic
amino acid side-chains, and the analogy with the α-helix are reported. Results suggest that …

The mimicry of protein tertiary structure by oligomers with unnatural backbones is a
significant contemporary research challenge. Among common elements of secondary …

The synthesis and structural characterization of hybrid α/γ-peptides resulting from a 1: 1 α→
γ residue substitution at cross-strand positions in a hairpin-forming α-peptide sequence are …

Hybrid Peptides: Direct Transformation of α/α, β-Unsaturated γ-Hybrid Peptides to α/γ-Hybrid
Peptide 12-Helices | Organic Letters ACS ACS Publications C&EN CAS Find my institution Log …

Exploring β-Hydroxy γ-Amino Acids (Statines) in the Design of Hybrid Peptide Foldamers |
Organic Letters ACS ACS Publications C&EN CAS Find my institution Log In Organic Letters …

Here, we are reporting a single-step transformation of N-protected α, β-unsaturated γ-amino
amides into 5, 5-disubstituted γ-lactams through a base-mediated new molecular …