Physicochemical stability of monoclonal antibodies: a review

Y Le Basle, P Chennell, N Tokhadze, A Astier… - Journal of …, 2020 - Elsevier
Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature.
In this work, we review the different mechanisms that can be linked to monoclonal antibodies …

How neutron scattering techniques benefit investigating structures and dynamics of monoclonal antibody

T Wang, J Chen, X Du, G Feng, T Dai, X Li… - Biochimica et Biophysica …, 2022 - Elsevier
Over the past several decades, great progresses have been made for the pharmaceutical
industry of monoclonal antibody (mAb). More and more mAb products were approved for …

Stability studies of 16 antibiotics for continuous infusion in intensive care units and for performing outpatient parenteral antimicrobial therapy

G Loeuille, E D'Huart, J Vigneron, YE Nisse, B Beiler… - Antibiotics, 2022 - mdpi.com
The use of continuous infusion to improve the therapeutic efficacy of time-dependent
antibiotics has been demonstrated. There is still a lack of data to safely perform these …

Long-term stability of diluted solutions of the monoclonal antibody rituximab

M Paul, V Vieillard, E Jaccoulet, A Astier - International journal of …, 2012 - Elsevier
As it is an important challenge for pharmacists to access the stability of monoclonal
antibodies because of the widespread of centralized preparation units, we conducted a …

Stability of ophthalmic atropine solutions for child myopia control

B Berton, P Chennell, M Yessaad, Y Bouattour… - Pharmaceutics, 2020 - mdpi.com
Myopia is an ophthalmic condition affecting more than 1/5th of the world population,
especially children. Low-dose atropine eyedrops have been shown to limit myopia evolution …

Compatibility and stability of pertuzumab and trastuzumab admixtures in iv infusion bags for coadministration

ZWK Glover, L Gennaro, S Yadav, B Demeule… - Journal of …, 2013 - Elsevier
The physical/chemical stability and potential interactions after diluting two immunoglobulin
G1 monoclonal antibodies (mAb), pertuzumab (Perjeta®) and trastuzumab (Herceptin®), in …

Compatibility of drugs administered as Y-site infusion in intensive care units: a systematic review

GC Lao, MR Reyes, JR Turet, MP Dot, DS Muner… - Medicina Intensiva …, 2020 - Elsevier
Objectives To gather all published information about the stability of drugs commonly used in
Intensive Care Units (ICU); evaluate the methodology of published data; and generate a …

Continuous infusions of meropenem in ambulatory care: clinical efficacy, safety and stability

L Manning, C Wright, PR Ingram, TJ Whitmore… - PLoS …, 2014 - journals.plos.org
Objectives Concerns regarding the clinical impact of meropenem instability in continuous
infusion (CI) devices may contribute to inconsistent uptake of this method of administration …

Formulation and Administration of Biological Medicinal Products”

I Krämer, J Thiesen, A Astier - Pharmaceutical Research, 2020 - Springer
Monoclonal antibody (Mabs) containing medicinal products are widely used in clinical
practice. Prior to parenteral administration, licensed Mab containing medicinal products are …

[HTML][HTML] Development and validation of an HPLC-DAD method for the simultaneous identification and quantification of topotecan, irinotecan, etoposide, doxorubicin …

S Sanogo, P Silimbani, R Gaggeri, C Masini - Arabian Journal of Chemistry, 2021 - Elsevier
The knowledge of the chemical stability of drugs prepared and administered in hospital is of
paramount importance for establishing the methods and times of their preparation, as well …