Prostate zones and cancer: lost in transition?
A Ali, A Du Feu, P Oliveira, A Choudhury… - Nature Reviews …, 2022 - nature.com
Localized prostate cancer shows great clinical, genetic and environmental heterogeneity;
however, prostate cancer treatment is currently guided solely by clinical staging, serum PSA …
however, prostate cancer treatment is currently guided solely by clinical staging, serum PSA …
[HTML][HTML] Understanding and targeting prostate cancer cell heterogeneity and plasticity
DG Tang - Seminars in cancer biology, 2022 - Elsevier
Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …
tumors in different patients manifest significant inter-patient heterogeneity with respect to …
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses
The treatment of low-risk primary prostate cancer entails active surveillance only, while high-
risk disease requires multimodal treatment including surgery, radiation therapy, and …
risk disease requires multimodal treatment including surgery, radiation therapy, and …
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets
Abstract c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression.
Although MYC is overexpressed in both early and metastatic disease and associated with …
Although MYC is overexpressed in both early and metastatic disease and associated with …
Single‐cell analysis of mouse and human prostate reveals novel fibroblasts with specialized distribution and microenvironment interactions
Stromal–epithelial interactions are critical to the morphogenesis, differentiation, and
homeostasis of the prostate, but the molecular identity and anatomy of discrete stromal cell …
homeostasis of the prostate, but the molecular identity and anatomy of discrete stromal cell …
Prostate organoids: emerging experimental tools for translational research
M Beshiri, S Agarwal, JJ Yin… - The Journal of Clinical …, 2023 - Am Soc Clin Investig
Organoid technology has provided new translational research opportunities in oncology, in
part by enabling the development of patient-representative living biobanks. Prostate cancer …
part by enabling the development of patient-representative living biobanks. Prostate cancer …
5‐Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia
Benign prostatic hyperplasia (BPH) is a progressive expansion of peri‐urethral prostate
tissue common in aging men. Patients with enlarged prostates are treated with 5‐alpha …
tissue common in aging men. Patients with enlarged prostates are treated with 5‐alpha …
Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts
Despite significant therapeutic advances in recent years, treatment of metastatic prostate
cancer (PCa) remains palliative, owing to the inevitable occurrence of drug resistance …
cancer (PCa) remains palliative, owing to the inevitable occurrence of drug resistance …
Stress relief: emerging methods to mitigate dissociation-induced artefacts
L Machado, F Relaix, P Mourikis - Trends in Cell Biology, 2021 - cell.com
The rapid progress of single-cell RNA-sequencing (scRNA-seq) at large scales has led to
what seemed impossible until recently: the generation of comprehensive transcriptional …
what seemed impossible until recently: the generation of comprehensive transcriptional …
Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis
The androgen receptor (AR)-signaling pathways are essential for prostate tumorigenesis.
Although significant effort has been devoted to directly targeting AR-expressing tumor cells …
Although significant effort has been devoted to directly targeting AR-expressing tumor cells …