Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Amyotrophic lateral sclerosis is characterized by the degeneration of upper and lower motor
neurons, yet an increasing number of studies in both mouse models and patients with …

Abstract Calorie restriction (CR)(25–40%) is the most commonly studied strategy for
curtailing age-related disease and has also been found to extend reproductive lifespan in …

Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated
by obesity. Dietary interventions can reverse metabolic declines and slow aging, although …

α-Estradiol (17aE2) treatment from 4 months of age extends life span in male mice and can
reduce neuroinflammatory responses in the hypothalamus of 12-month-old males. Although …

Pharmacological treatments can extend mouse lifespan, but lifespan effects often differ
between sexes. 17‐α estradiol (17aE2), a less feminizing structural isomer of 17‐β estradiol …

Estrogen receptor alpha (ERα) plays a crucial role in reproductive function in both sexes. It
also mediates cellular responses to estrogens in multiple nonreproductive organ systems …

Menopause is a natural physiological process in older women that is associated with
reduced estrogen production and results in increased risk for obesity, diabetes, and …

Aging is the greatest risk factor for most chronic diseases. The somatotropic axis is one of
the most conserved biological pathways that regulates aging across species. 17α-Estradiol …