Microbial secondary metabolites (MSMs) have played and continue to play a highly
significant role in the drug discovery and development process. Genetically, MSM chemical …

Endophytes constitute a remarkably multifarious group of microorganisms ubiquitous in
plants and maintain an imperceptible association with their hosts for at least a part of their …

Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …

Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

Genomic sequence data have revealed the presence of a large fraction of putatively silent
biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary …

Natural products from microorganisms are a crucial source for novel therapeutics. Even so, it
seems that many valuable compounds are overlooked when culturing microbes under …

For years, fungi have served as repositories of bioactive secondary metabolites that form the
backbone of many existing drugs. With the global rise in infections associated with …

Many reports have been published on bioprospecting of endophytic fungi capable of
producing high value bioactive molecules like, paclitaxel, vincristine, vinblastine …

Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited
natural product profiles with enhanced chemical diversity demonstrating that small-molecule …