Sleep spindles: mechanisms and functions
LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …
Functional characterization of human pluripotent stem cell-derived models of the brain with microelectrode arrays
A Pelkonen, C Pistono, P Klecki, M Gómez-Budia… - Cells, 2021 - mdpi.com
Human pluripotent stem cell (hPSC)-derived neuron cultures have emerged as models of
electrical activity in the human brain. Microelectrode arrays (MEAs) measure changes in the …
electrical activity in the human brain. Microelectrode arrays (MEAs) measure changes in the …
Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night
During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep
spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops …
spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops …
Oscillatory-Quality of sleep spindles links brain state with sleep regulation and function
Here, we characterized the dynamics of sleep spindles, focusing on their damping, which we
estimated using a metric called oscillatory-Quality (o-Quality), derived by fitting an …
estimated using a metric called oscillatory-Quality (o-Quality), derived by fitting an …
Temporal associations between sleep slow oscillations, spindles and ripples
The systems consolidation of memory during slow‐wave sleep (SWS) is thought to rely on a
dialogue between hippocampus and neocortex that is regulated by an interaction between …
dialogue between hippocampus and neocortex that is regulated by an interaction between …
Travelling spindles create necessary conditions for spike-timing-dependent plasticity in humans
Sleep spindles facilitate memory consolidation in the cortex during mammalian non-rapid
eye movement sleep. In rodents, phase-locked firing during spindles may facilitate spike …
eye movement sleep. In rodents, phase-locked firing during spindles may facilitate spike …
Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall
Declarative memory encoding, consolidation, and retrieval require the integration of
elements encoded in widespread cortical locations. The mechanism whereby such “binding” …
elements encoded in widespread cortical locations. The mechanism whereby such “binding” …
Posterior hippocampal spindle ripples co-occur with neocortical theta bursts and downstates-upstates, and phase-lock with parietal spindles during NREM sleep in …
X Jiang, J Gonzalez-Martinez… - Journal of …, 2019 - Soc Neuroscience
Human anterior and posterior hippocampus (aHC, pHC) differ in connectivity and behavioral
correlates. Here we report physiological differences in humans of both sexes. During NREM …
correlates. Here we report physiological differences in humans of both sexes. During NREM …
The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex
Describing intracortical laminar organization of interictal epileptiform discharges (IED) and
high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of …
high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of …
Theta bursts precede, and spindles follow, cortical and thalamic downstates in human NREM sleep
CE Gonzalez, RA Mak-McCully, BQ Rosen… - Journal of …, 2018 - Soc Neuroscience
Since their discovery, slow oscillations have been observed to group spindles during non-
REM sleep. Previous studies assert that the slow-oscillation downstate (DS) is preceded by …
REM sleep. Previous studies assert that the slow-oscillation downstate (DS) is preceded by …