Sleep spindles: mechanisms and functions

LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

Functional characterization of human pluripotent stem cell-derived models of the brain with microelectrode arrays

A Pelkonen, C Pistono, P Klecki, M Gómez-Budia… - Cells, 2021 - mdpi.com
Human pluripotent stem cell (hPSC)-derived neuron cultures have emerged as models of
electrical activity in the human brain. Microelectrode arrays (MEAs) measure changes in the …

Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night

L Muller, G Piantoni, D Koller, SS Cash, E Halgren… - Elife, 2016 - elifesciences.org
During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep
spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops …

Oscillatory-Quality of sleep spindles links brain state with sleep regulation and function

C Blanco-Duque, SA Bond, LB Krone, JP Dufour… - Science …, 2024 - science.org
Here, we characterized the dynamics of sleep spindles, focusing on their damping, which we
estimated using a metric called oscillatory-Quality (o-Quality), derived by fitting an …

Temporal associations between sleep slow oscillations, spindles and ripples

CN Oyanedel, E Durán, N Niethard… - European Journal of …, 2020 - Wiley Online Library
The systems consolidation of memory during slow‐wave sleep (SWS) is thought to rely on a
dialogue between hippocampus and neocortex that is regulated by an interaction between …

Travelling spindles create necessary conditions for spike-timing-dependent plasticity in humans

CW Dickey, A Sargsyan, JR Madsen… - Nature …, 2021 - nature.com
Sleep spindles facilitate memory consolidation in the cortex during mammalian non-rapid
eye movement sleep. In rodents, phase-locked firing during spindles may facilitate spike …

Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall

CW Dickey, IA Verzhbinsky, X Jiang… - Proceedings of the …, 2022 - National Acad Sciences
Declarative memory encoding, consolidation, and retrieval require the integration of
elements encoded in widespread cortical locations. The mechanism whereby such “binding” …

Posterior hippocampal spindle ripples co-occur with neocortical theta bursts and downstates-upstates, and phase-lock with parietal spindles during NREM sleep in …

X Jiang, J Gonzalez-Martinez… - Journal of …, 2019 - Soc Neuroscience
Human anterior and posterior hippocampus (aHC, pHC) differ in connectivity and behavioral
correlates. Here we report physiological differences in humans of both sexes. During NREM …

The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex

D Fabo, V Bokodi, JP Szabó, E Tóth, P Salami… - Scientific reports, 2023 - nature.com
Describing intracortical laminar organization of interictal epileptiform discharges (IED) and
high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of …

Theta bursts precede, and spindles follow, cortical and thalamic downstates in human NREM sleep

CE Gonzalez, RA Mak-McCully, BQ Rosen… - Journal of …, 2018 - Soc Neuroscience
Since their discovery, slow oscillations have been observed to group spindles during non-
REM sleep. Previous studies assert that the slow-oscillation downstate (DS) is preceded by …