How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …

The gain-of-function MUC5B promoter variant rs35705950 is the dominant risk factor for
developing idiopathic pulmonary fibrosis (IPF). Here we show in humans that MUC5B, a …

Our understanding of motile cilia and their role in disease has increased tremendously over
the last two decades, with critical information and insight coming from the analysis of mouse …

Primary ciliary dyskinesia (PCD) is a hereditary genetic disorder caused by the lack of motile
cilia or the assembxly of dysfunctional ones. This rare human disease affects 1 out of 10,000 …

Motile cilia are dynamic hair-like structures covering epithelial surfaces in multiple organs.
The periodic coordinated beating of cilia creates waves propagating along the surface …

Pediatric hydrocephalus is characterized by an abnormal accumulation of cerebrospinal
fluid (CSF) and is one of the most common congenital brain abnormalities. However, little is …

SARS-CoV-2 initiates infection in the conducting airways, where mucociliary clearance
inhibits pathogen penetration. However, it is unclear how mucociliary clearance impacts …

Primary and motile cilia are eukaryotic organelles that perform crucial roles in cellular
signalling and motility. Intraflagellar transport (IFT) contributes to the formation of the highly …

Cystic fibrosis (CF) is a genetic disease hallmarked by aberrant ion transport that results in
delayed mucus clearance, chronic infection, and progressive lung function decline. Several …

We have developed a human bronchial epithelial (HBE) cell and endothelial cell co-cultured
microfluidic model to mimic the in vivo human airway. This airway-on-a-chip was designed …