Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …

A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

Tibetans do not exhibit increased hemoglobin concentration at high altitude. We describe a
high-frequency missense mutation in the EGLN1 gene, which encodes prolyl hydroxylase 2 …

Humans have adapted to the chronic hypoxia of high altitude in several locations, and
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …

Medical problems occur at high altitude because of the low inspired Po2, which is caused by
the reduced barometric pressure. The classical physiological responses to high altitude …

In the early 2000s, as India was emerging as a global superpower, a key development
project off the southern Indian coast was thwarted by intense opposition. The construction of …

A comprehensive update to this preeminent and accessible text, this fifth edition of a
bestseller was developed as a response to man's attempts to climb unaided to higher …

Abstract Simonson, Tatum S. Altitude adaptation: A glimpse through various lenses. High Alt
Med Biol 16: 125–137, 2015.—Recent availability of genome-wide data from highland …

Living at high altitude is one of the most difficult challenges that humans had to cope with
during their evolution. Whereas several genomic studies have revealed some of the genetic …

High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …