Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Increasing data indicate that inflammation and alterations in glutamate neurotransmission
are two novel pathways to pathophysiology in mood disorders. The primary goal of this …

Background Neuroinflammation is one of the most important processes in secondary injury
after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) …

Aims Mild traumatic brain injury (mTBI) is an important risk factor for cognitive impairment.
Despite intense efforts to develop efficient treatments, the current therapies are not often …

Occupational injuries and toxicant exposures lead to the development of neuroinflammation
by activating distinct mechanistic signaling cascades that ultimately culminate in the …

The post-injury inflammatory response is a key mediator in long-term recovery from
traumatic brain injury (TBI). Moreover, the immune response to TBI, mediated by microglia …

Glutamate is the most abundant neurotransmitter of the central nervous system, as the
majority of neurons use glutamate as neurotransmitter. It is also well known that this …

Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation
occurs after both stroke subtypes and contributes to neuronal injury and damage to the …

With the increasing prevalence of Parkinson's disease (PD), there is an immediate need to
interdict disease signs and symptoms. In recent years this need was met through therapeutic …

Background Traumatic brain injury (TBI) is one of the major contributors to disability and
death worldwide. Glutamate-mediated excitotoxicity, one of the secondary injuries occurring …