Thiazole-containing compounds as therapeutic targets for cancer therapy
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …
development, and several new anticancer agents of natural and synthetic origin have been …
[HTML][HTML] Recent advances of tubulin inhibitors targeting the colchicine binding site for cancer therapy
M Hawash - Biomolecules, 2022 - mdpi.com
Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …
Recent applications of 1, 3-thiazole core structure in the identification of new lead compounds and drug discovery
Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …
and discovery. It is widely found in diverse pharmacologically active substances and in …
Thiazole in the targeted anticancer drug discovery
Cancer is known as one of the main causes of death in the world; and many compounds
have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile …
have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile …
Recent developments in tubulin polymerization inhibitors: an overview
Microtubules are protein biopolymers formed through polymerization of heterodimers of α-
and β-tubulins. Disruption of microtubules can induce cell cycle arrest in G 2-M phase and …
and β-tubulins. Disruption of microtubules can induce cell cycle arrest in G 2-M phase and …
Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: a decade update
K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …
[HTML][HTML] Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery
SR Alizadeh, SM Hashemi - Medicinal Chemistry Research, 2021 - Springer
Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …
2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents
Y Wan, J Long, H Gao, Z Tang - European Journal of Medicinal Chemistry, 2021 - Elsevier
Cancer has been the second heath killer being next only to cardiovascular diseases in
human society. Although many efforts have been taken for cancer therapy and many …
human society. Although many efforts have been taken for cancer therapy and many …
[HTML][HTML] Tubulin-interactive stilbene derivatives as anticancer agents
R Mikstacka, T Stefański, J Różański - Cellular and molecular …, 2013 - degruyter.com
Microtubules are dynamic polymers that occur in eukaryotic cells and play important roles in
cell division, motility, transport and signaling. They form during the process of polymerization …
cell division, motility, transport and signaling. They form during the process of polymerization …
Design, computational studies, synthesis and biological evaluation of thiazole-based molecules as anticancer agents
S Patel, R Patle, P Parameswaran, A Jain… - European Journal of …, 2019 - Elsevier
Background Abolition of cancer warrants effective treatment modalities directed towards
specific pathways dysregulated in tumor proliferation and survival. The antiapoptotic Bcl-2 …
specific pathways dysregulated in tumor proliferation and survival. The antiapoptotic Bcl-2 …