Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi

SC Kessler, YH Chooi - Natural Product Reports, 2022 - pubs.rsc.org
Covering up to June 2021 Ribosomally synthesized and post-translationally modified
peptides (RiPPs) from fungi are an underexplored class of natural products, despite their …

Mushroom toxins: chemistry and toxicology

X Yin, AA Yang, JM Gao - Journal of agricultural and food …, 2019 - ACS Publications
Mushroom consumption is a global tradition that is still gaining popularity. However, foraging
for wild mushrooms and accidental ingestion of toxic mushrooms can result in serious illness …

Comparative Mitogenome Analysis Reveals Mitochondrial Genome Differentiation in Ectomycorrhizal and Asymbiotic Amanita Species

Q Li, X He, Y Ren, C Xiong, X Jin, L Peng… - Frontiers in …, 2020 - frontiersin.org
In this present study, we assembled and analyzed the mitogenomes of two asymbiotic and
six ectomycorrhizal Amanita species based on next-generation sequencing data. The size of …

Lateral flow immunoassay (LFIA) for the detection of lethal amatoxins from mushrooms

CS Bever, CA Adams, RM Hnasko, LW Cheng… - PloS one, 2020 - journals.plos.org
The mushroom poison that causes the most deaths is the class of toxins known as
amatoxins. Current methods to sensitively and selectively detect these toxins are limited by …

Genes and evolutionary fates of the amanitin biosynthesis pathway in poisonous mushrooms

H Luo, HE Hallen-Adams, Y Lüli… - Proceedings of the …, 2022 - National Acad Sciences
The deadly toxin α-amanitin is a bicyclic octapeptide biosynthesized on ribosomes. A
phylogenetically disjunct group of mushrooms in Agaricales (Amanita, Lepiota, and …

Invasive Californian death caps develop mushrooms unisexually and bisexually

YW Wang, MC McKeon, H Elmore, J Hess… - Nature …, 2023 - nature.com
Canonical sexual reproduction among basidiomycete fungi involves the fusion of two
haploid individuals of different mating types, resulting in a heterokaryotic mycelial body …

The Cyclic Peptide Toxins of Amanitaand Other Poisonous Mushrooms

J Walton - 2018 - Springer
Poisonous mushrooms have fascinated and horrified people for thousands of years.
Mushrooms in the large and charismatic genus Amanita in particular have featured in …

Pangenomics of the death cap mushroom Amanita phalloides, and of Agaricales, reveals dynamic evolution of toxin genes in an invasive range

MT Drott, SC Park, Y Wang, L Harrow… - The ISME …, 2023 - academic.oup.com
Abstract The poisonous European mushroom Amanita phalloides (the “death cap”) is
invading California. Whether the death caps' toxic secondary metabolites are evolving as it …

Discovery of novel fungal RiPP biosynthetic pathways and their application for the development of peptide therapeutics

E Vogt, M Künzler - Applied microbiology and biotechnology, 2019 - Springer
Bioactive peptide natural products are an important source of therapeutics. Prominent
examples are the antibiotic penicillin and the immunosuppressant cyclosporine which are …

Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

CM Czekster, H Ludewig, SA McMahon… - Nature …, 2017 - nature.com
Peptide macrocycles are promising therapeutic molecules because they are protease
resistant, structurally rigid, membrane permeable, and capable of modulating protein …