[HTML][HTML] Recent therapeutic trends and promising targets in triple negative breast cancer

SY Hwang, S Park, Y Kwon - Pharmacology & therapeutics, 2019 - Elsevier
Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast
cancer (TNBC) comprises around 15~ 20% of breast cancers. Conventional chemotherapy …

Leptin as a predictive marker for metabolic syndrome

AA Ghadge, AA Khaire - Cytokine, 2019 - Elsevier
Metabolic syndrome poses a major threat on human health affecting the quality of life.
Adipose tissue is an important organ which plays a crucial role in the pathogenesis of …

Efficacy and safety of co-administered once-weekly cagrilintide 2· 4 mg with once-weekly semaglutide 2· 4 mg in type 2 diabetes: a multicentre, randomised, double …

JP Frias, S Deenadayalan, L Erichsen, FK Knop… - The Lancet, 2023 - thelancet.com
Background Combining the GLP-1 receptor agonist semaglutide with the long-acting amylin
analogue cagrilintide has weight-loss benefits; the impact on glycated haemoglobin (HbA …

[HTML][HTML] Endocrine disruptors leading to obesity and related diseases

D Petrakis, L Vassilopoulou, C Mamoulakis… - International journal of …, 2017 - mdpi.com
The review aims to comprehensively present the impact of exposure to endocrine disruptors
(EDs) in relation to the clinical manifestation of obesity and related diseases, including …

[HTML][HTML] Overview and new insights into the metabolic syndrome: risk factors and emerging variables in the development of type 2 diabetes and cerebrocardiovascular …

MR Hayden - Medicina, 2023 - mdpi.com
Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily
increasing globally and seems to parallel the increasing prevalence of obesity. It consists of …

[HTML][HTML] Insulin signaling impairment in the brain as a risk factor in Alzheimer's disease

C Hölscher - Frontiers in aging neuroscience, 2019 - frontiersin.org
Type 2 diabetes is a risk factor for developing Alzheimer's disease (AD). The underlying
mechanism that links up the two conditions seems to be the de-sensitization of insulin …

Type 2 diabetes and viral infection; cause and effect of disease

TT Wensveen, D Gašparini, D Rahelić… - Diabetes research and …, 2021 - Elsevier
The recent pandemic of COVID-19 has made abundantly clear that Type 2 diabetes (T2D)
increases the risk of more frequent and more severe viral infections. At the same time, pro …

[HTML][HTML] Leptin, both bad and good actor in cancer

C Jiménez-Cortegana, A López-Saavedra… - Biomolecules, 2021 - mdpi.com
Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in
obesity. Leptin exerts many different actions on various tissues and systems, including …

[HTML][HTML] Alzheimer's disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links

M Rojas, M Chávez-Castillo, J Bautista… - World Journal of …, 2021 - ncbi.nlm.nih.gov
At present, Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two highly
prevalent disorders worldwide, especially among elderly individuals. T2DM appears to be …

[HTML][HTML] GDM-complicated pregnancies: focus on adipokines

M Mallardo, S Ferraro, A Daniele, E Nigro - Molecular Biology Reports, 2021 - Springer
Gestational diabetes mellitus (GDM) is a serious complication of pregnancy and is defined
as a state of glucose intolerance that is first diagnosed and arises during gestation. Although …