Neurodegenerative diseases are increasing in prevalence and place a significant burden on
society. The causes are multifactorial and complex, and increasing evidence suggests a …

Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron
disease. It is characterized by the progressive degeneration of upper and lower motor …

Observational studies have shown gut microbiota changes in sporadic Creutzfeldt-Jakob
disease patients, but the causal relationship remains unknown. We aimed to determine any …

Amyotrophic Lateral Sclerosis (ALS) is a highly fatal neurodegenerative disorder
characterized by the progressive wasting and paralysis of voluntary muscle. Despite …

Amyotrophic lateral sclerosis (ALS) is an untreatable and clinically heterogeneous condition
primarily affecting motor neurons. The ongoing quest for reliable biomarkers that mirror the …

High-dimensional biomedical datasets have become easier to collect in the last two
decades with the advent of multi-omic and single-cell experiments. These can generate over …

The mechanisms underlying the earlier onset and male predominance of amyotrophic
lateral sclerosis (ALS), the most common form of human motoneuron disease, are poorly …