Context The present summary of the European Association of Urology (EAU) guidelines is
based on the latest guidelines on male sexual health published in March 2021, with a last …

Abstract Phosphodiesterase 5 (PDE5) is one of the most well-studied phosphodiesterases
(PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated …

Purpose: Men who ejaculate before or shortly after penetration, without a sense of control,
and who experience distress related to this condition may be diagnosed with premature …

Premature ejaculation (PE) and poor ejaculatory control are multidimensional sexual
symptoms estimated to affect almost one-third of men, severely impairing the overall quality …

Introduction Sexual dysfunction in men is common, and optimal treatment is complex.
Although several systematic reviews concerning treatment approaches exist, a …

Introduction Many men experience distressing issues regarding the timing of orgasm and
ejaculation, such as premature ejaculation (PE) and delayed ejaculation (DE). Despite …

The arrival of Pfizer's blue pill Sildenafil in 1998 brought a great relief both to patient and
physician signalling the start of a great era of medical therapy in sexual medicine. Since …

Rationale Challenges in drug development for psychiatric disorders have left much room for
the introduction of novel treatments with better therapeutic efficacies and indices. As a result …

Introduction Besides erectile dysfunction, premature ejaculation (PE) is the most frequent
male sexual disorder and shows a high level of bother and distress. The negative …

To assess the comparative efficacy and safety of drug treatments for premature ejaculation.
A systemic review and Bayesian network meta‐analysis were executed on randomised …