To transform common low-molecular-weight (LMW) cationic polymers, such as
polyethylenimine (PEI), to highly efficient gene vectors would be of great significance but …

To improve the efficiency of poly (D, L-lactic-co-glycolic acid)(PLGA) nanoparticles (NP) as a
gene carrier for the transfection of human mesenchymal stem cells (hMSCs), we developed …

A Novel poly [2-hydroxyethyl methacrylate-Lactide-dimethylaminoethyl methacrylate
quaternary ammonium alkyl halide][P (HEMA-LA-MADQUAT)] copolymer was synthesized …

Natural polycations, such as poly (L-lysine)(PLL) and chitosan (CS), have inherent
superiority as non-viral vectors due to their unparalleled biocompatibility and …

Amines have been extensively involved in vector design thus far, however, their clinical
translation has been impeded by several obstacles: cytotoxicity, polyplex serum instability …

Cationic polymers (polycations) are promising gene vectors that are conveniently
synthesized and easily modified. In order to study the relationship between structures and …

Recent progress in gene therapy has opened the door for various human diseases. The
greatest challenge that gene vectors still face is the ability to sufficiently deliver nucleic acid …

A kind of novel multifunctional modules based on zinc (II)-coordinative cyclen has been
developed, which is utilized to modify low molecular weight polyethylenimine (LMWPEI) …

A novel pH-responsive Fe 3 O 4/poly (2-succinyloxyethylmethacrylate-co-
methylmethacrylate)(poly (SEMA-co-MMA)) nanocomposite was designed for anticancer …

Cationic polymers have emerged as appealing nonviral gene vectors for decades, which,
however, suffer from the paradox between low molecular weight and high transfection …