Mitochondria form dynamic networks in the cell that are balanced by the flux of iterative
fusion and fission events of the organelles. It is now appreciated that mitochondrial fission …

The large GTP ase dynamin is the first protein shown to catalyze membrane fission.
Dynamin and its related proteins are essential to many cell functions, from endocytosis to …

Endocytosis is required for internalization of micronutrients and turnover of membrane
components. Endophilin has been assigned as a component of clathrin-mediated …

Summary VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-
anchored protein that helps generate tethers between the ER and other membranes through …

Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …

A potentially important aspect in the regulation of tumour metastasis is endocytosis. This
process consists of internalisation of cell-surface receptors via pinocytosis, phagocytosis or …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

This brief overview of endocytic trafficking is written in honor of Renate Fuchs, who retires
this year. In the mid-1980s, Renate pioneered studies on the ion-conducting properties of …

Abstract Dynamin-related protein 1 (Drp1) is essential for mitochondrial and peroxisomal
fission. Recent studies propose that Drp1 does not sever but rather constricts mitochondrial …