Single-cell metabolomics with mass spectrometry enables a large variety of metabolites to
be simultaneously detected from individual cells, without any preselection or labelling, to …

Over the past decade, systems biology and plant-omics have increasingly become the main
stream in plant biology research. New developments in mass spectrometry and …

Proteomic analysis of limited samples and single cells requires specialized methods that
prioritize high sensitivity and minimize sample loss. Consequently, sample preparation is …

Lysosomes are critical for cellular metabolism and are heterogeneously involved in various
cellular processes. The ability to measure lysosomal metabolic heterogeneity is essential for …

Cellular heterogeneity, especially in some important diseased cells like tumor cells, acts as
an invisible driver for disease development like cancer progression in the tumor ecosystem …

Capillary electrophoresis mass spectrometry (CE-MS) is an emerging analytical tool for
microscale biological sample analysis that offers high separation resolution, low detection …

Cell is the most basic structural unit and plays a vital role in the function of organism.
Studying the heterogeneity of cells, especially the qualitative and quantitative analysis of …

Tissues and other cell populations are highly heterogeneous at the cellular level, owing to
differences in expression and modifications of proteins, polynucleotides, metabolites, and …

Biological processes unfold across broad spatial and temporal dimensions, and
measurement of the underlying molecular world is essential to their understanding …

Single-cell metabolomics is expected to deliver fast and dynamic information on cell
function; therefore, it requires rapid analysis of a wide variety of very small quantities of …