Abbreviations: ACT activated clotting time; APTT activated partial thromboplastin time; AT
antithrombin; AT-III antithrombin III; CI confidence interval; DVT deep vein thrombosis; GP …

Thrombi are composed of fibrin and blood cells and may form in any part of the
cardiovascular system, including veins, arteries, the heart, and the microcirculation. Because …

This article about unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH)
is part of the Seventh American College of Chest Physicians Conference on Antithrombotic …

This article focuses on new antithrombotic drugs that are in or are entering phase 3 clinical
testing. Development of these new agents was prompted by the limitations of existing …

This chapter focuses on new antithrombotic drugs that are in phase II or III clinical testing.
Development of these new agents was prompted by limitations of existing antiplatelet …

BACKGROUND: Patients with acute coronary syndromes (ACS; unstable angina and non–
ST-segment elevation myocardial infarction) are at significant risk for death and myocardial …

Activated platelets secrete a negatively charged polymer, polyphosphate (polyP). Here, we
explore the interactions of polyP with fibrin (ogen) and its effect on fibrin structure and …

Background: Measurement of thrombin generation by calibrated automated thrombography
(CAT) could fulfill the requirements of a global test of coagulability and is potentially …

A fraction of fibrinogen contains a differently spliced γ chain called γ′, which presents itself
mainly as heterodimer with the common γA chain as γA/γ′ fibrinogen. The γ′ chain differs …

Precise modulation of thrombin activity throughout the hemostatic response is essential for
efficient cessation of bleeding while preventing inappropriate clot growth or dissemination …