Over the last 15 years several biological markers of bone turnover have been developed
with increased specificity and sensitivity. In osteoporosis clinical studies, the IOF and IFCC …

Coupling during bone remodeling refers to the spatial and temporal coordination of bone
resorption with bone formation. Studies have assessed the subtle interactions between …

Recent literature suggested that cells of the microenvironment of tumors could be abnormal
as well. To address this hypothesis in multiple myeloma (MM), we studied bone marrow …

Opioids are powerful analgesics but also drugs of abuse. Because opioid addicts are
susceptible to certain infections, opioids have been suspected to suppress the immune …

Lysophosphatidic acid (LPA, 1‐radyl‐2‐hydroxy‐sn‐glycero‐3‐phosphate) is the prototype
member of a family of lipid mediators and second messengers. LPA and its naturally …

Osteoporosis is a systemic bone disease that affects more than 200 million people
worldwide and is caused by the disruption of the equilibrium between osteoclastic bone …

Evidence from epidemiological studies and animal models suggests a link between high
levels of dietary fat intake and risk of breast cancer. In addition, obesity, in which circulating …

Abstract Sphingosine-1-phosphate (S1P), the bioactive product of sphingosine kinase (SK)
activation, is a survival factor for endothelial cells. The mechanism of SK-mediated survival …

The measurement of bone turnover markers is useful for the clinical investigation of patients
with osteoporosis. Among the available biochemical markers, the measurements of serum …

Recent studies demonstrate widespread expression of ghrelin among tissues and have
uncovered its pleiotropic nature. We have examined gene expression of ghrelin and its two …