In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

Nuclear magnetic resonance (NMR) spectroscopy is a well-established method for
analyzing protein structure, interaction, and dynamics at atomic resolution and in various …

Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

In-cell NMR is an isotope-aided multi-dimensional NMR technique that enables
observations of conformations and functions of proteins in living cells at the atomic level …

In recent years, better instrumentation and greater computing power have enabled the
imaging of elusive biomolecule dynamics in cells, driving many advances in understanding …

Protein structure investigations are usually carried out in vitro under conditions far from their
native environment in the cell. Differences between in-cell and in vitro structures of proteins …

Investigating proteins 'at work'in a living environment at atomic resolution is a major goal of
molecular biology, which has not been achieved even though methods for the three …

Distance measurement in the nanometer range by electron paramagnetic resonance
spectroscopy (EPR) in combination with site-directed spin labeling is a very powerful tool to …