Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids
and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is …

This protocol shows how to obtain a detailed glycan compositional and structural profile from
purified glycoproteins or protein mixtures, and it can be used to distinguish different isobaric …

1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …

Post-translational modifications define the functional and structural plasticity of proteins in
archaea, prokaryotes and eukaryotes. Multi-site protein modification modulates protein …

The identification of serum biomarkers has lead to improvements in the detection and
diagnosis of cancer, and combinations of these biomarkers have increased further their …

Glycoproteins are known to exhibit multiple biological functions. In order to assign distinct
functional properties to defined structural features, detailed information on the respective …

Diagnosis of the type of glomerular disease that causes the nephrotic syndrome is
necessary for appropriate treatment and typically requires a renal biopsy. The goal of this …

Human saliva harbours proteins of clinical relevance and about 30% of blood proteins are
also present in saliva. This highlights that saliva can be used for clinical applications just as …

The emergence of the biopharmaceutical industry represented a major revolution for
modern medicine, through the development of recombinant therapeutic proteins that brought …