Houpo paiqi mixture promotes intestinal motility in constipated rats by modulating gut microbiota and activating 5-HT-cAMP-PKA signal pathway

R Wang, X Lu, L Zhao, W Zhang… - Journal of applied …, 2023 - academic.oup.com
Aims Constipation is a common functional gastrointestinal disorder, which needs more
effective treatment approaches. Houpo Paiqi Mixture (HPPQM) is a type of Chinese patent …

[HTML][HTML] Short chain fatty acids and colon motility in a mouse model of irritable bowel syndrome

IF Shaidullov, DM Sorokina, FG Sitdikov… - BMC …, 2021 - Springer
Background Irritable bowel syndrome (IBS) is defined as a multifactorial disorder associated
with visceral hypersensitivity, altered gut motility and dysfunction of the brain-gut axis. Gut …

[HTML][HTML] Melanin-concentrating hormone promotes anxiety and intestinal dysfunction via basolateral amygdala in mice

X He, Y Li, N Zhang, J Huang, X Ming, R Guo… - Frontiers in …, 2022 - frontiersin.org
The limbic system plays a pivotal role in stress-induced anxiety and intestinal disorders, but
how the functional circuits between nuclei within the limbic system are engaged in the …

Puerarin from Pueraria lobata alleviates the symptoms of irritable bowel syndrome-diarrhea

QS Wang, YL Wang, WY Zhang, KD Li, XF Luo… - Food & Function, 2021 - pubs.rsc.org
As a functional bowel disorder, irritable bowel syndrome (IBS), especially IBS-diarrhea (IBS-
D), affects approximately 9–20% of the population worldwide. Classical treatments for IBS …

Overlapping symptoms of functional gastrointestinal disorders: current challenges and the role of traditional Chinese medicine

J Huang, T Chen, J Zhang, X Ma, F Wang… - The American Journal …, 2023 - World Scientific
Several functional gastrointestinal disorders (FGIDs) have overlapping symptoms, and,
consequently, developing treatment strategies based on symptomatology poses a challenge …

[HTML][HTML] Mechanistic insights of Cucumis melo L. seeds for gastrointestinal muscle spasms through calcium signaling pathway–related gene regulation networks in …

M Wahid, F Saqib, S Akhtar, A Ali, TE Tallei… - Computers in Biology …, 2023 - Elsevier
Background In addition to the nutritional benefits of Cucumis melo L., herbalists in Pakistan
and India employ seeds to treat various ailments. This study aimed to determine the …

[HTML][HTML] Tongxie Anchang decoction relieves visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome rats by regulating the NGF/TrkA signaling …

X Tan, W Pei, C Xie, Z Wang, J Liu, Y Cheng… - Evidence-Based …, 2021 - hindawi.com
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease characterized by
visceral hypersensitivity-related abdominal pain, in which diarrhea-predominant IBS (IBS-D) …

How can we develop better antispasmodics for irritable bowel syndrome?

S Ranjbar, SA Seyednejad, S Nikfar… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal (GI) disease.
Antispasmodics are a heterogeneous group of drugs that tackle IBS-associated altered …

Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway

S Zhang, D Tian, Z Xia, F Yang, Y Chen, Z Yao… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Chang-Kang-Fang (CKF), originated from
traditional Chinese medicine (TCM) formulas, has been utilized to treat diarrhea …

[HTML][HTML] Shugan Decoction Alleviates Colonic Dysmotility in Female SERT-Knockout Rats by Decreasing M3 Receptor Expression

Y Wang, Y Dong, E Wang, Y Meng, Z Bi… - Frontiers in …, 2020 - frontiersin.org
Background Irritable bowel syndrome (IBS) is a functional gut disease characterized by
visceral hypersensitivity and gut motor dysfunction. Serotonin (5-hydroxytryptamine, 5-HT) is …