Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …

Whether kidney proximal tubule harbors a scattered population of epithelial stem cells is a
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …

The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis.
Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in …

Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …

Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

Understanding the mechanisms of nephron repair is critical for the design of new therapeutic
approaches to treat kidney disease. The kidney can repair after even a severe insult, but …

Recently we have established that the kidney tubular epithelium is repaired by surviving
epithelial cells. It is not known, however, whether a population of intratubular adult …

The scarcity of transplant allografts for diseased organs has prompted efforts at tissue
regeneration using seeded scaffolds, an approach hampered by the enormity of cell types …

Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction
with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem …