Malignant ascites in ovarian cancer: cellular, acellular, and biophysical determinants of molecular characteristics and therapy response
Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
Biology of cancer; from cellular and molecular mechanisms to developmental processes and adaptation
IG Motofei - Seminars in Cancer Biology, 2022 - Elsevier
Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …
Stiffness increases with myofibroblast content and collagen density in mesenchymal high grade serous ovarian cancer
V Mieulet, C Garnier, Y Kieffer, T Guilbert, F Nemati… - Scientific reports, 2021 - nature.com
Women diagnosed with high-grade serous ovarian cancers (HGSOC) are still likely to
exhibit a bad prognosis, particularly when suffering from HGSOC of the Mesenchymal …
exhibit a bad prognosis, particularly when suffering from HGSOC of the Mesenchymal …
[HTML][HTML] Tumor-derived extracellular vesicles promote activation of carcinoma-associated fibroblasts and facilitate invasion and metastasis of ovarian cancer by …
Y Cui, D Wang, M Xie - Frontiers in cell and developmental …, 2021 - pmc.ncbi.nlm.nih.gov
Ovarian cancer (OC) is a lethal gynecological malignancy. Extracellular vesicles (EVs) are
crucial media in cell-to-cell communication by carrying microRNAs (miRs). The current study …
crucial media in cell-to-cell communication by carrying microRNAs (miRs). The current study …
Integrated cancer tissue engineering models for precision medicine
Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are
highly organized and interconnected organ systems. Tumor cells reside in complex …
highly organized and interconnected organ systems. Tumor cells reside in complex …
The role of cancer stem cells and mechanical forces in ovarian cancer metastasis
Ovarian cancer is an extremely lethal gynecologic disease; with the high-grade serous
subtype predominantly associated with poor survival rates. Lack of early diagnostic …
subtype predominantly associated with poor survival rates. Lack of early diagnostic …
Ascitic fluid shear stress in concert with hepatocyte growth factor drive stemness and chemoresistance of ovarian cancer cells via the c-Met-PI3K/Akt-miR-199a-3p …
AA Hassan, M Artemenko, MKS Tang, Z Shi… - Cell Death & …, 2022 - nature.com
Overcoming drug resistance is an inevitable challenge to the success of cancer treatment.
Recently, in ovarian cancer, a highly chemoresistant tumor, we demonstrated an important …
Recently, in ovarian cancer, a highly chemoresistant tumor, we demonstrated an important …
[HTML][HTML] Magnetic resonance elastography reconstruction for anisotropic tissues
Elastography has become widely used clinically for characterising changes in soft tissue
mechanics that are associated with altered tissue structure and composition. However, some …
mechanics that are associated with altered tissue structure and composition. However, some …
Compressive stimulation enhances ovarian cancer proliferation, invasion, chemoresistance, and mechanotransduction via CDC42 in a 3D bioreactor
This report investigates the role of compressive stress on ovarian cancer in a 3D custom
built bioreactor. Cells within the ovarian tumor microenvironment experience a range of …
built bioreactor. Cells within the ovarian tumor microenvironment experience a range of …
Select Per-and polyfluoroalkyl substances (PFAS) induce resistance to carboplatin in ovarian cancer cell lines
Per-and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants
associated with adverse reproductive outcomes including reproductive cancers in women …
associated with adverse reproductive outcomes including reproductive cancers in women …