Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …

Gene regulatory networks drive the specific transcriptional programmes responsible for the
diversification of cell types during the development of multicellular organisms. Although our …

Enhancers are distal DNA elements believed to loop and contact promoters to control gene
expression. Recently, we found diffraction-sized transcriptional condensates at genes …

Developmental programming involves the accurate conversion of signalling levels and
dynamics to transcriptional outputs. The transcriptional relay in the Notch pathway relies on …

Enhancer dynamics: Unraveling the mechanism of transcriptional bursting | Science Advances
news careers commentary Journals Science Science brought to you byGoogle Indexer Log in …

Whether phase-separation is involved in the organization of the transcriptional machinery
and if it aids or inhibits the transcriptional process is a matter of intense debate. In this Mini …

The cyclic AMP response element (CRE) binding protein (CREB) is a transcription factor that
contains a 280-residue N-terminal transactivation domain and a basic leucine zipper that …

Highlights•Microenvironments are local high concentrations of multiple nuclear factors.•
Microenvironments form due to protein–protein and protein–chromatin interactions.•Local …

Eukaryotic transcription factors activate gene expression with their DNA-binding domains
and activation domains. DNA-binding domains bind the genome by recognizing structurally …

Sequencing-based mapping of ensemble pairwise interactions among regulatory elements
support the existence of topological assemblies known as promoter-enhancer hubs or …