Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Liquid–liquid phase separation in tumor biology

X Tong, R Tang, J Xu, W Wang, Y Zhao, X Yu… - Signal Transduction and …, 2022 - nature.com
Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Slow TCA flux and ATP production in primary solid tumours but not metastases

CR Bartman, DR Weilandt, Y Shen, WD Lee, Y Han… - Nature, 2023 - nature.com
Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …

Screening membraneless organelle participants with machine-learning models that integrate multimodal features

Z Chen, C Hou, L Wang, C Yu, T Chen… - Proceedings of the …, 2022 - National Acad Sciences
Protein self-assembly is one of the formation mechanisms of biomolecular condensates.
However, most phase-separating systems (PS) demand multiple partners in biological …

Eosinophil extracellular traps drive asthma progression through neuro-immune signals

Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li… - Nature Cell …, 2021 - nature.com
Eosinophilic inflammation is a feature of allergic asthma. Despite mounting evidence
showing that chromatin filaments released from neutrophils mediate various diseases, the …

Roadmap on digital holography-based quantitative phase imaging

V Balasubramani, M Kujawińska, C Allier, V Anand… - Journal of …, 2021 - mdpi.com
Quantitative Phase Imaging (QPI) provides unique means for the imaging of biological or
technical microstructures, merging beneficial features identified with microscopy …

Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate

DC Carrettiero, MC Almeida, AP Longhini… - Nature …, 2022 - nature.com
The formation of membraneless organelles can be a proteotoxic stress control mechanism
that locally condenses a set of components capable of mediating protein degradation …

Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer

LW Zheng, CC Liu, KD Yu - Journal of Hematology & Oncology, 2023 - Springer
Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …

M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression

D Lv, S Ding, L Zhong, J Tu, H Li, H Yao, Y Zou, Z Zeng… - Oncogene, 2022 - nature.com
Despite advances in clinical diagnosis and treatment, the prognosis of patients with
osteosarcoma (OS) remains poor, and the treatment efficacy has plateaued. Therefore, it is …

Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?

S Mirzaei, MDA Paskeh, Y Saghari, A Zarrabi… - International Journal of …, 2022 - Elsevier
Transforming growth factor-beta (TGF-β) is a member of a family of secreted cytokines with
vital biological functions in cells. The abnormal expression of TGF-β signaling is a common …