Introduction All receptors that interact with effector systems to modulate the intracellular
levels of a second messenger appear to do so via the intermediacy of members of a family of …

Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for
membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G …

Myristoylation of seven different alpha subunits of guanine nucleotide-binding regulatory
proteins (G proteins) was examined by expressing these proteins in monkey kidney COS …

Signaling via G-protein-coupled receptors (GPCRs) is crucial to many physiological and
pathophysiological processes in multicellular organisms, and GPCRs themselves are …

Recent studies on the structural and chemical properties of insulin have shown that the
insulin hexamer is an allosteric protein capable of adopting three distinct conformations …

G protein heterocomplex undergoes dissociation and association during its functional cycle.
Quantitative measurements of α and βγ subunit binding have been difficult due to a very …

The effect of activation of the alpha-subunit (s) of the stimulatory guanine-nucleotide-binding
protein, Gs, on levels of this polypeptide (s) associated with the plasma membrane of L6 …

Considerable debate has focused on the molecular identity of the guanine-nucleotide-
binding proteins (G-proteins) in adipose tissue which can be detected following pertussis …

1. Whole‐cell calcium currents of bullfrog sympathetic neurones were partially inhibited by
noradrenaline (NA), chicken‐II‐luteinizing hormone‐releasing hormone (LHRH), muscarine …

As assessed both by cholera-toxin-catalysed ADP-ribosylation and by immunoblotting with
an anti-peptide antiserum raised against the C-terminal decapeptide of forms of Gs alpha …