Single molecule fluorescence and nuclear magnetic resonance spectroscopy (NMR) are two
very powerful techniques for the analysis of intrinsically disordered proteins (IDPs). Both …

DNA polymerases are intrinsically dynamic macromolecular machines. The purpose of this
review is to describe the single-molecule Förster resonance energy transfer (smFRET) …

Cytosine methylation plays an essential role in many biological processes, such as
nucleosome inactivation and regulation of gene expression. The modulation of DNA …

An essential requirement for the use of fluorescent dyes in biomedicine, molecular biology,
biochemistry, biophysics and optical imaging is their (covalent) attachment to biomolecules …

DNA-ligasen spelen een cruciale rol bij het herstellen van DNA-breuken en worden
geassocieerd met kanker en immuundeficiëntiesyndromen. Het begrijpen van hun structuur …