Toolbox for distal C–H bond functionalizations in organic molecules
Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …
Fluorine and fluorinated motifs in the design and application of bioisosteres for drug design
NA Meanwell - Journal of medicinal chemistry, 2018 - ACS Publications
The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …
versatility as a bioisostere and it has found application as a substitute for lone pairs of …
Metabolic and pharmaceutical aspects of fluorinated compounds
BM Johnson, YZ Shu, X Zhuo… - Journal of medicinal …, 2020 - ACS Publications
The applications of fluorine in drug design continue to expand, facilitated by an improved
understanding of its effects on physicochemical properties and the development of synthetic …
understanding of its effects on physicochemical properties and the development of synthetic …
The most common functional groups in bioactive molecules and how their popularity has evolved over time
P Ertl, E Altmann, JM McKenna - Journal of medicinal chemistry, 2020 - ACS Publications
The concept of functional groups (FGs), sets of connected atoms that can determine the
intrinsic reactivity of the parent molecule and in part are responsible for the overall …
intrinsic reactivity of the parent molecule and in part are responsible for the overall …
Modern approaches for asymmetric construction of carbon–fluorine quaternary stereogenic centers: synthetic challenges and pharmaceutical needs
New methods for preparation of tailor-made fluorine-containing compounds are in extremely
high demand in nearly every sector of chemical industry. The asymmetric construction of …
high demand in nearly every sector of chemical industry. The asymmetric construction of …
Applications of fluorine in medicinal chemistry
EP Gillis, KJ Eastman, MD Hill… - Journal of medicinal …, 2015 - ACS Publications
The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …
about the unique properties associated with this unusual element and how to deploy it with …
Fluorine-containing pharmaceuticals approved by the FDA in 2020: Synthesis and biological activity
Thirteen new fluorine-containing drugs, which have been granted approval by the US Food
and Drug Administration (FDA) in 2020, are profiled in this review. Therapeutic areas of …
and Drug Administration (FDA) in 2020, are profiled in this review. Therapeutic areas of …
Radical fluoroalkylation of isocyanides with fluorinated sulfones by visible‐light photoredox catalysis
The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visible‐
light photoredox catalysis. A wide range of readily available mono‐, di‐, and trifluoromethyl …
light photoredox catalysis. A wide range of readily available mono‐, di‐, and trifluoromethyl …
Organofluorine chemistry: Promising growth areas and challenges
LV Politanskaya, GA Selivanova… - Russian Chemical …, 2019 - iopscience.iop.org
Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …
area of organic chemistry. Fluorine present in a molecule largely determines its specific …
Wonderful fusion of organofluorine chemistry and decarboxylation strategy
P Xiao, X Pannecoucke, JP Bouillon… - Chemical Society …, 2021 - pubs.rsc.org
Decarboxylation strategy has been emerging as a powerful tool for the synthesis of fluorine-
containing organic compounds that play important roles in various fields such as …
containing organic compounds that play important roles in various fields such as …