Carbohydrates possess a variety of distinct features with stereochemistry playing a
particularly important role in distinguishing their structure and function. Monosaccharide …

Glycosylation is one of the most significant and abundant posttranslational modifications in
mammalian cells. It mediates a wide range of biofunctions, including cell adhesion, cell …

Abstract Changes in the glycome of human proteins and cells are associated with the
progression of multiple diseases such as Alzheimer's, diabetes mellitus, many types of …

N-Glycosylation is a fundamentally important protein modification with a major impact on
glycoprotein characteristics such as serum half-life and receptor interaction. More than half …

The structural complexity of glycans makes their characterization challenging, not only
because of the presence of various isomeric forms of the precursor molecule but also …

Mass spectrometry (MS) offers unparalleled qualitative and quantitative chemical
information. While increasingly considered a universal detector, the limitations of MS to …

The diversification of the chemical properties and biological functions of proteins is attained
through posttranslational modifications, such as glycosylation. Glycans, which are covalently …

Ion mobility-mass spectrometry (IM-MS) has become a powerful tool for glycan structural
characterization due to its ability to separate isomers and provide collision cross section …

Protein glycosylation is involved in many biological processes and physiological functions.
Despite the recent advances in LC-MS/MS methodologies, the profiling of site-specific …

Early stage detection and cancer treatment demand the identification of reliable biomarkers.
Over the past decades, efforts have been devoted to assess the variation of glycosylation …