Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …

Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC)
limits drug penetration into the tumor and is associated with poor prognosis. Here, we …

The role of tumor microenvironment in cancer progression is gaining significant attention. It
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …

The stroma in solid tumors contains a variety of cellular phenotypes and signaling pathways
associated with wound healing, leading to the concept that a tumor behaves as a wound that …

Previous studies have investigated whether tumor-associated macrophages (TAMs) play
tumorigenic and immunosuppressive roles to encourage cancer development, but the role of …

Much effort has been made to generate human skin organ in the laboratory. Yet, the current
models are limited due to the lack of many critical biological and structural features of the …

Neutrophils are the most abundant type of leukocytes in the blood, traditionally regarded as
the first immune responders to infections and inflammations. In the context of tumors …