The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

During pregnancy, several tightly coordinated and regulated processes take place to enable
proper fetal development and gestational success. The formation and development of the …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal
axis with the observation that G protein-coupled receptor 54 (GPR54) is required in mice …

Context: Mutation of the G protein-coupled receptor 54 is associated with a failure of
reproductive function. The endogenous neuropeptide agonist for G protein-coupled receptor …

The G protein-coupled receptor GPR54 (AXOR12, OT7T175) is central to acquisition of
reproductive competency in mammals. Peptide ligands (kisspeptins) for this receptor are …

Trophoblast research over the past decades has underlined the striking similarities between
the proliferative, migratory and invasive properties of placental cells and those of cancer …

The G protein-coupled receptor Gpr54 and its ligand metastin (derived from the Kiss1 gene
product kisspeptin) are key gatekeepers of sexual maturation. Gpr54 knockout mice …

BACKGROUND Kisspeptin is a key regulator of hypothalamic gonadotropin-releasing
hormone (GnRH) neurons and is essential for reproductive health. A specific kisspeptin …

Kisspeptin is the peptide product of the KiSS‐1 gene and the endogenous agonist for the
GPR54 receptor. Recent evidence suggests the kisspeptin/GPR54 system is a key regulator …