Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

Endosomes are dynamic intracellular compartments that control the sorting of a constant
stream of different transmembrane cargos either for ESCRT‐mediated degradation or for …

Targeted protein degradation can provide advantages over inhibition approaches in the
development of therapeutic strategies. Lysosome-targeting chimeras (LYTACs) harness …

The Commander complex is required for endosomal recycling of diverse transmembrane
cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies …

Following endocytosis into the endosomal network, integral membrane proteins undergo
sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here …

Eukaryotic cells traffic proteins and lipids between different compartments using protein-
coated vesicles and tubules. The retromer complex is required to generate cargo-selective …

Because both the host and pathogen require iron, the innate immune response carefully
orchestrates control over iron metabolism to limit its availability during times of infection …

The tubular endolysosomal network is a quality control system that ensures the proper
delivery of internalized receptors to specific subcellular destinations in order to maintain …

Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the
death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD …

Retromer is a peripheral membrane protein complex that coordinates multiple vesicular
trafficking events within the endolysosomal system. Here, we demonstrate that retromer is …