Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

G Tardiolo, P Bramanti, E Mazzon - Molecules, 2018 - mdpi.com
N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific
interest for decades due to its important medical applications. It also represents a nutritional …

[HTML][HTML] Neurosteroids as regulators of neuroinflammation

C Yilmaz, K Karali, G Fodelianaki, A Gravanis… - Frontiers in …, 2019 - Elsevier
Neuroinflammation is a physiological protective response in the context of infection and
injury. However, neuroinflammation, especially if chronic, may also drive …

N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

R Bavarsad Shahripour, MR Harrigan… - Brain and …, 2014 - Wiley Online Library
Background There is an expanding field of research investigating the benefits of medicines
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …

Role of reactive oxygen species (ROS) in apoptosis induction

HU Simon, A Haj-Yehia, F Levi-Schaffer - Apoptosis, 2000 - Springer
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis
induction under both physiologic and pathologic conditions. Interestingly, mitochondria are …

Molecular mechanisms of N-acetylcysteine actions

M Zafarullah, WQ Li, J Sylvester, M Ahmad - Cellular and Molecular Life …, 2003 - Springer
Oxidative stress generated by an imbalance between reactive oxygen species (ROS) and
antioxidants contributes to the pathogenesis of arthritis, cancer, cardiovascular, liver and …

[PDF][PDF] Reactive oxygen species in tumor progression

P Storz - Front biosci, 2005 - researchgate.net
Introduction 3. Reactive oxygen species in tumor growth and cellular survival 4. Reactive
oxygen species in cell motility and metastasis formation 5. Generation of reactive oxygen …

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

LJ Yant, Q Ran, L Rao, H Van Remmen… - Free Radical Biology …, 2003 - Elsevier
Lipid peroxidation has been implicated in a variety of pathophysiological processes,
including inflammation, atherogenesis, neurodegeneration, and the ageing process …

Redox regulation of cellular signalling

H Kamata, H Hirata - Cellular signalling, 1999 - Elsevier
Extracellular stimuli elicit a variety of responses, such as cell proliferation and differentiation,
through the cellular signalling system. Binding of growth factors to the respective receptor …

Oxidative stress and reactive oxygen species: a review of their role in ocular disease

L Ung, U Pattamatta, N Carnt… - Clinical …, 2017 - portlandpress.com
For many years, oxidative stress arising from the ubiquitous production of reactive oxygen
species (ROS) has been implicated in the pathogenesis of various eye diseases. While …

Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death

JS Bains, CA Shaw - Brain research reviews, 1997 - Elsevier
Oxidative stress has been implicated in both normal aging and in various
neurodegenerative disorders and may be a common mechanism underlying various forms …