Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

EM Frickel, CA Hunter - Journal of Experimental Medicine, 2021 - rupress.org
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

Seizing control: How dense granule effector proteins enable Toxoplasma to take charge

MW Panas, JC Boothroyd - Molecular microbiology, 2021 - Wiley Online Library
Control of the host cell is crucial to the Apicomplexan parasite, Toxoplasma gondii, while it
grows intracellularly. To achieve this goal, these single‐celled eukaryotes export a series of …

Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

A Rosenberg, LD Sibley - Cell host & microbe, 2021 - cell.com
Toxoplasma gondii translocates effector proteins into its host cell to subvert various host
pathways. T. gondii effector TgIST blocks the transcription of interferon-stimulated genes to …

Epigenetic Reprogramming in Host-Parasite Coevolution: The Toxoplasma Paradigm

MA Hakimi - Annual review of microbiology, 2022 - annualreviews.org
Like many intracellular pathogens, the protozoan parasite Toxoplasma gondii has evolved
sophisticated mechanisms to promote its transmission and persistence in a variety of hosts …

[HTML][HTML] Cell type-and species-specific host responses to Toxoplasma gondii and its near relatives

ZS Wong, SLS Borrelli, CC Coyne, JP Boyle - International journal for …, 2020 - Elsevier
Toxoplasma gondii is remarkably unique in its ability to successfully infect vertebrate hosts
from multiple phyla and can successfully infect most cells within these organisms. The …

[HTML][HTML] Host-Pathogen Interactions Focus: Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

EM Frickel, CA Hunter - The Journal of Experimental Medicine, 2021 - ncbi.nlm.nih.gov
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

Toxoplasma gondii: Asexual Cycle in the Intermediate Host

M Gissot - Lifecycles of Pathogenic Protists in Humans, 2022 - Springer
Toxoplasma gondii is a parasite of major medical and veterinary importance with a high
incidence in humans. This coccidian parasite has a complex life cycle with felines as its …