Piwi-interacting RNAs (piRNAs) and PIWI proteins play key functions in a wide range of
biological and developmental processes through the regulation of cellular mRNAs, in …

LINE-1 (L1) is a class of autonomous mobile genetic elements that form somatic mosaicisms
in various tissues of the organism. The activity of L1 retrotransposons is strictly controlled by …

Background P-element–induced wimpy testis (PIWI)–interacting RNAs (piRNAs) are short
(21 to 35 nucleotides in length) and noncoding and are found almost exclusively in germ …

In animals, PIWI-interacting RNAs (piRNAs) silence transposons, fight viral infections, and
regulate gene expression. piRNA biogenesis concludes with 3′ terminal trimming and 2 …

Mitochondria are organelles responsible for several functions involved in cellular balance,
including energy generation and apoptosis. For decades now, it has been well-known that …

Abstract PIWI-interacting RNAs (piRNAs), small noncoding RNAs 24–35 nucleotides long,
are essential for animal fertility. They play critical roles in a range of functions, including …

The classic roles of mitochondria in energy production, metabolism, and apoptosis have
been well defined. However, a growing body of evidence suggests that mitochondria are …

The intermitochondrial cement (IMC) is a prominent germ granule that locates among
clustered mitochondria in mammalian germ cells. Serving as a key platform for Piwi …

The intermitochondrial cement (IMC) and chromatoid body (CB) are posited as central sites
for piRNA activity in mice, with MIWI initially assembling in the IMC for piRNA processing …

PIWI proteins and their associated piRNAs act to silence transposons and promote
gametogenesis. Murine PIWI proteins MIWI, MILI, and MIWI2 have multiple arginine and …