Molecular bases of VEGFR-2-mediated physiological function and pathological role

X Wang, AM Bove, G Simone, B Ma - Frontiers in Cell and …, 2020 - frontiersin.org
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial
roles in vasculogenesis and angiogenesis. Angiogenesis is an important mechanism in …

Current advances in structure–function relationships and dose-dependent effects of human milk oligosaccharides

J Wang, MS Chen, RS Wang, JQ Hu, S Liu… - Journal of Agricultural …, 2022 - ACS Publications
HMOs (human milk oligosaccharides) are the third most important nutrient in breast milk. As
complex glycans, HMOs play an important role in regulating neonatal intestinal immunity …

3D-Cultured Vascular-Like Networks Enable Validation of Vascular Disruption Properties of Drugs In Vitro

P Yavvari, A Laporte, L Elomaa… - … in Bioengineering and …, 2022 - frontiersin.org
Vascular-disrupting agents are an interesting class of anticancer compounds because of
their combined mode of action in preventing new blood vessel formation and disruption of …

Isatin-hydrazones with multiple Receptor Tyrosine Kinases (RTKs) inhibitory activity and in-silico binding mechanism

HS Al-Salem, M Arifuzzaman, IS Issa, AFMM Rahman - Applied Sciences, 2021 - mdpi.com
Recently, we have reported a series of isatin hydrazone, two of them, namely, 3-((2, 6-
dichlorobenzylidene) hydrazono) indolin-2-one (1) and 3-((2-chloro-6-fluorobenzylidene) …

Human milk oligosaccharides in cord blood are altered in gestational diabetes and stimulate feto-placental angiogenesis in vitro

D Hoch, W Brandl, J Strutz, HC Köfeler… - Nutrients, 2021 - mdpi.com
(1) Background: Human milk oligosaccharides (HMOs) are present in maternal serum during
pregnancy and their composition is altered in gestational diabetes (GDM). HMOs are also in …

Recent updates on potential of VEGFR-2 small-molecule inhibitors as anticancer agents

PJ Chaudhari, AR Nemade, AA Shirkhedkar - RSC advances, 2024 - pubs.rsc.org
The vascular endothelial growth factor receptor (VEGFR) system is the key component for
controlling angiogenesis in cancer cells. Blocking vascular endothelial growth factor …

Redefining the significance of quinoline containing compounds as potent VEGFR-2 inhibitors for cancer therapy

J Reang, V Sharma, V Yadav, RK Tonk… - Medicinal Chemistry …, 2024 - Springer
Vascular endothelial growth factor receptor-2 (VEGFR-2), a tyrosine kinase receptor (TKR) is
frequently overexpressed in most of the cancers. It plays a crucial part in tumor angiogenesis …

Hyperosmolarity benefits cartilage regeneration by enhancing expression of chondrogenic markers and reducing inflammatory markers

S Alinezhad-Bermi, M Kabiri, I Rad, S Irani… - In Vitro Cellular & …, 2021 - Springer
Application of hyperosmolarity can be a promising strategy to promote chondrogenic
differentiation in adipose-derived mesenchymal stem cells (ADSCs). Growth factors may …

Anti-Angiogenic Property of Free Human Oligosaccharides

B Bae, H Kim, H Park, YJ Koh, SJ Bae, KT Ha - Biomolecules, 2021 - mdpi.com
Angiogenesis, a fundamental process in human physiology and pathology, has attracted
considerable attention owing to its potential as a therapeutic strategy. Vascular endothelial …

Cancer Vaccine and Chemotherapeutic Agent: Advances in Cancer Management

A Patel, S Patel, S Dongre, P Srivastava… - Cancer Vaccination …, 2025 - taylorfrancis.com
Carcinogenesis is a multifactorial chronic process that encompasses a variety of factors.
Monotherapy of chemotherapy would not be sufficient to eradicate resistant tumor cells and …