[HTML][HTML] Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics
Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …
[HTML][HTML] Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review
The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …
serious therapeutic consequences. The source of variability can be traced back to …
[HTML][HTML] Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
Z Vinarov, B Abrahamsson, P Artursson… - Advanced Drug Delivery …, 2021 - Elsevier
Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …
centuries, modern drug discovery and development pipelines challenge conventional …
[HTML][HTML] Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review
M Vertzoni, P Augustijns, M Grimm, M Koziolek… - European journal of …, 2019 - Elsevier
Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …
[PDF][PDF] Simulated biological fluids with possible application in dissolution testing
MRC Marques, R Loebenberg, M Almukainzi - Dissolution Technol, 2011 - academia.edu
This literature review is a compilation of the composition and, in most cases, the preparation
instructions for simulated biological fluids that may be used as dissolution media in the …
instructions for simulated biological fluids that may be used as dissolution media in the …
The Biopharmaceutics Classification System: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC
Y Tsume, DM Mudie, P Langguth, GE Amidon… - European Journal of …, 2014 - Elsevier
Abstract The Biopharmaceutics Classification System (BCS) has found widespread utility in
drug discovery, product development and drug product regulatory sciences. The …
drug discovery, product development and drug product regulatory sciences. The …
In vitro models for the prediction of in vivo performance of oral dosage forms
ES Kostewicz, B Abrahamsson, M Brewster… - European Journal of …, 2014 - Elsevier
Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …
Assessing the performance of amorphous solid dispersions
A Newman, G Knipp, G Zografi - Journal of pharmaceutical sciences, 2012 - Elsevier
The characterization and performance of stable amorphous solid dispersion systems were
evaluated in 40 research papers reporting active pharmaceutical ingredient (API) dissolution …
evaluated in 40 research papers reporting active pharmaceutical ingredient (API) dissolution …
In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API …
E Sjögren, B Abrahamsson, P Augustijns… - European Journal of …, 2014 - Elsevier
This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …
In-vitro simulation of luminal conditions for evaluation of performance of oral drug products: Choosing the appropriate test media
C Markopoulos, CJ Andreas, M Vertzoni… - European Journal of …, 2015 - Elsevier
Background Biorelevant media for evaluation of dosage form performance in the
gastrointestinal lumen were first introduced in the late 1990s. Since then, a variety of …
gastrointestinal lumen were first introduced in the late 1990s. Since then, a variety of …