Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …

The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …

This literature review is a compilation of the composition and, in most cases, the preparation
instructions for simulated biological fluids that may be used as dissolution media in the …

Abstract The Biopharmaceutics Classification System (BCS) has found widespread utility in
drug discovery, product development and drug product regulatory sciences. The …

Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …

The characterization and performance of stable amorphous solid dispersion systems were
evaluated in 40 research papers reporting active pharmaceutical ingredient (API) dissolution …

This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …

Background Biorelevant media for evaluation of dosage form performance in the
gastrointestinal lumen were first introduced in the late 1990s. Since then, a variety of …