Engaging innate immunity in HIV-1 cure strategies
Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
The humanized mouse model: what added value does it offer for HIV research?
L Baroncini, S Bredl, KP Nicole, RF Speck - Pathogens, 2023 - mdpi.com
In the early 2000s, novel humanized mouse models based on the transplantation of human
hematopoietic stem and progenitor cells (HSPCs) into immunocompromised mice were …
hematopoietic stem and progenitor cells (HSPCs) into immunocompromised mice were …
Enhanced development of functional human NK cells in NOD-scid-IL2rg mice expressing human IL15
KE Aryee, LM Burzenski, LC Yao… - FASEB …, 2022 - repository.escholarship.umassmed …
Human innate immunity plays a critical role in tumor surveillance and in immunoregulation
within the tumor microenvironment. Natural killer (NK) cells are innate lymphoid cells that …
within the tumor microenvironment. Natural killer (NK) cells are innate lymphoid cells that …
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
The majority of naturally elicited antibodies against the HIV-1 envelope glycoproteins (Env)
are non-neutralizing (nnAbs) because they are unable to recognize the Env trimer in its …
are non-neutralizing (nnAbs) because they are unable to recognize the Env trimer in its …
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies
ABSTRACT HIV-1 envelope glycoprotein (Env) conformation substantially impacts antibody-
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity
CJ Fritschi, S Anang, Z Gong… - Proceedings of the …, 2023 - National Acad Sciences
Binding to the host cell receptors, CD4 and CCR5/CXCR4, triggers large-scale
conformational changes in the HIV-1 envelope glycoprotein (Env) trimer [(gp120/gp41) 3] …
conformational changes in the HIV-1 envelope glycoprotein (Env) trimer [(gp120/gp41) 3] …
HIV-1 Vpu restricts Fc-mediated effector functions in vivo
Non-neutralizing antibodies (nnAbs) can eliminate HIV-1-infected cells via antibody-
dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in the …
dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in the …
Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity
ABSTRACT HIV-1 evades antibody-dependent cellular cytotoxicity (ADCC) responses not
only by controlling Env conformation and quantity at the cell surface but also by altering NK …
only by controlling Env conformation and quantity at the cell surface but also by altering NK …
Human hematopoietic stem cell engrafted IL-15 transgenic NSG mice support robust NK cell responses and sustained HIV-1 infection
Mice reconstituted with human immune systems are instrumental in the investigation of HIV-
1 pathogenesis and therapeutics. Natural killer (NK) cells have long been recognized as a …
1 pathogenesis and therapeutics. Natural killer (NK) cells have long been recognized as a …
V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins
ABSTRACT CD4-mimetic compounds (CD4mcs) bind the human immunodeficiency virus
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …