Trauma-induced coagulopathy

EE Moore, HB Moore, LZ Kornblith, MD Neal… - Nature reviews Disease …, 2021 - nature.com
Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Thromboinflammation in acute injury: infections, heatstroke, and trauma

T Iba, J Helms, M Levi, JH Levy - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
Tissue microcirculation is essential for the maintenance of organ homeostasis. Following
acute infections, activation of coagulation and inflammation, which are critical …

Fibrinolysis shutdown correlation with thromboembolic events in severe COVID-19 infection

FL Wright, TO Vogler, EE Moore, HB Moore… - Journal of the American …, 2020 - Elsevier
Background COVID-19 predisposes patients to a prothrombotic state with demonstrated
microvascular involvement. The degree of hypercoagulability appears to correlate with …

High D dimers and low global fibrinolysis coexist in COVID19 patients: what is going on in there?

C Ibañez, J Perdomo, A Calvo, C Ferrando… - Journal of thrombosis …, 2021 - Springer
Backgroud COVID-19 coagulopathy linked to increased D-dimer levels has been associated
with high mortality (Fei Z et al. in Clinical course and risk factors for mortality of adult …

Fibrinolysis shutdown and thrombosis in a COVID-19 ICU

C Creel-Bulos, SC Auld, M Caridi-Scheible, NA Barker… - Shock, 2021 - journals.lww.com
Abstract The coronavirus disease (COVID-19) pandemic has threatened millions of lives
worldwide with severe systemic inflammation, organ dysfunction, and thromboembolic …

Fibrinolysis shutdown in COVID-19: clinical manifestations, molecular mechanisms, and therapeutic implications

JP Meizoso, HB Moore, EE Moore - Journal of the American College of …, 2021 - Elsevier
The COVID-19 pandemic has introduced a global public health threat unparalleled in our
history. The most severe cases are marked by ARDS attributed to microvascular thrombosis …

Tranexamic acid: current use in obstetrics, major orthopedic, and trauma surgery

J Wong, RB George, CM Hanley, C Saliba… - Canadian Journal of …, 2021 - Springer
Abstract Purpose In this Continuing Professional Development module, we review the
practical pharmacology of tranexamic acid and its clinical use in trauma, obstetrics, and …

Immuno-thrombotic complications of COVID-19: implications for timing of surgery and anticoagulation

CM Bunch, EE Moore, HB Moore, MD Neal… - Frontiers in …, 2022 - frontiersin.org
Early in the coronavirus disease 2019 (COVID-19) pandemic, global governing bodies
prioritized transmissibility-based precautions and hospital capacity as the foundation for …

Perioperative considerations in management of the severely bleeding coagulopathic patient

G Erdoes, D Faraoni, A Koster, ME Steiner… - …, 2023 - pubs.asahq.org
Inherited and acquired coagulopathy are frequently associated with major bleeding in
severe trauma, cardiac surgery with cardiopulmonary bypass, and postpartum hemorrhage …

The pathophysiology and management of hemorrhagic shock in the polytrauma patient

A Fecher, A Stimpson, L Ferrigno… - Journal of clinical …, 2021 - mdpi.com
The recognition and management of life-threatening hemorrhage in the polytrauma patient
poses several challenges to prehospital rescue personnel and hospital providers. First …