The CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally
differentiated 'senescent'cells with reduced proliferative capacity and altered functional …

The decline of the immune system appears to be an intractable consequence of aging,
leading to increased susceptibility to infections, reduced effectiveness of vaccination and …

CD8+ T cell exhaustion represents a major hallmark of chronic HIV infection. Two key
transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin …

T cell exhaustion has a major role in failure to control chronic infection. High expression of
inhibitory receptors, including PD-1, and the inability to sustain functional T cell responses …

The treatment or cure of HIV infection by cell and gene therapy has been a goal for decades.
Recent advances in both gene editing and chimeric antigen receptor (CAR) technology …

CD57+ expression in T lymphocytes has been recognized for decades as a marker of in vitro
replicative senescence. In recent years, accumulating evidences have pointed on the utility …

T cell dysfunction is an important feature of many chronic viral infections. In particular, it was
shown that programmed death-1 (PD-1) regulates T cell dysfunction during chronic …

Several inflammatory biomarkers appear to add to our ability to predict mortality or
opportunistic disease in HIV-infected individuals. Before biomarkers will be useful, it will be …

The inevitable decline of CD4T cells in untreated infection with the Human
immunodeficiency virus (HIV) is due in large part to apoptosis, one type of programmed cell …

Simple Summary The primary issue of adoptive cell therapy is the poor in vivo persistence.
In this context, it is necessary to clarify the fundamental mechanisms of T cell dysfunction …