Serine/glycine biosynthesis and one‑carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

Introduction We previously developed a tandem mass spectrometry-based label-free
targeted metabolomics analysis framework coupled to two distinct chromatographic …

Aging is a systemic process, which is a risk factor for impaired physiological functions, and
finally death. The molecular mechanisms driving aging process and the associated cognitive …

Metabolic reprogramming is observed across all cancer types. Indeed, the success of many
classic chemotherapies stems from their targeting of cancer metabolism. Contemporary …

Upregulation of serine biosynthesis pathway activity is an increasingly apparent feature of
many cancers. Most notably, the first rate-limiting enzyme of the pathway, phosphoglycerate …

Emerging evidence suggests that cancer metabolism is closely associated to the serine
biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is …

Breast cancer is the second leading cause of cancer-related deaths among women and
90% of these mortalities can be attributed to progression to metastatic disease. In particular …

Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these
associations are in clinical trials for leukemia treatment. By integrating chromatin-focused …

EWS/FLI is the defining mutation of Ewing sarcoma. This oncogene drives malignant
transformation and progression and occurs in a genetic background characterized by few …