Hallmarks of cardiovascular ageing

M Abdellatif, PP Rainer, S Sedej… - Nature Reviews …, 2023 - nature.com
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

The aging heart in focus: The advanced understanding of heart failure with preserved ejection fraction

Z Zhang, Y Wang, X Chen, C Wu, J Zhou, Y Chen… - Ageing Research …, 2024 - Elsevier
Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of heart failure (HF)
cases, making it the most common type of HF, and its prevalence continues to increase in …

Empagliflozin protects against heart failure with preserved ejection fraction partly by inhibiting the senescence-associated STAT1–STING axis

Y Shi, L Zhao, J Wang, X Liu, Y Bai, H Cong… - Cardiovascular …, 2024 - Springer
Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without
effective therapies. Empagliflozin (EMPA) improves cardiovascular outcomes in HFpEF …

Anti-ageing interventions for the treatment of cardiovascular disease

M Abdellatif, ST Schmid, A Fuerlinger… - Cardiovascular …, 2024 - academic.oup.com
As the global demographic landscape continues to shift towards an aged population, so
does the medical and socioeconomic burden of cardiovascular diseases. Indeed, ageing is …

Echocardiographic characterization of age-and sex-associated differences in cardiac function and morphometry in nonhuman primates

MC Florio, L Fusini, G Tamborini, C Morrell… - GeroScience, 2024 - Springer
Aging per se is a major risk factor for cardiovascular diseases and is associated with
progressive changes in cardiac structure and function. Rodent models are commonly used …

Hypertension and obesity independently drive hypertrophy and alter mitochondrial metabolism in a mouse model of heart failure with preserved ejection fraction

B Werbner, SL Stephens, D Stuart… - Physiological …, 2024 - Wiley Online Library
Heart failure with preserved ejection fraction (HFpEF) has recently emerged as an
insidiously and increasingly prevalent heart failure phenotype. HFpEF often occurs in the …

[引用][C] Insuficiencia cardíaca con fracción de eyección preservada:¿ Un síndrome geriátrico?

P Blanco