Candida auris Genetics and Emergence

A Chowdhary, K Jain, N Chauhan - Annual Review of …, 2023 - annualreviews.org
Candida auris is a multidrug-resistant fungal pathogen that presents a serious threat to
global human health. Since the first reported case in 2009 in Japan, C. auris infections have …

The high osmolarity glycerol (HOG) pathway in fungi

H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

Nutrient and stress sensing in pathogenic yeasts

JC Rutherford, YS Bahn, B Van Den Berg… - Frontiers in …, 2019 - frontiersin.org
More than 1.5 million fungal species are estimated to live in vastly different environmental
niches. Despite each unique host environment, fungal cells sense certain fundamentally …

Isobavachalcone exhibits antifungal and antibiofilm effects against C. albicans by disrupting cell wall/membrane integrity and inducing apoptosis and autophagy

W Qian, J Lu, C Gao, Q Liu, W Yao, T Wang… - Frontiers in Cellular …, 2024 - frontiersin.org
Isobavachalcone (IBC) is a natural flavonoid with multiple pharmacological properties. This
study aimed to evaluate the efficacy of IBC against planktonic growth and biofilms of …

Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution

H David, AP Solomon - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Candida albicans-mediated vulvovaginal candidiasis (VVC) is a significant challenge in
clinical settings, owing to the inefficacy of current antifungals in modulating virulence …

The two-component signal transduction system and its regulation in Candida albicans

B Liao, X Ye, X Chen, Y Zhou, L Cheng, X Zhou, B Ren - Virulence, 2021 - Taylor & Francis
Candida albicans, which can cause superficial and life-threatening systemic infections, is
the most common opportunistic fungal pathogen in the human microbiome. The two …

A case for two-component signaling systems as antifungal drug targets

E Shor, N Chauhan - PLoS pathogens, 2015 - journals.plos.org
The recent outbreak of fungal meningitis caused by Exserohilum rostratum in patients
receiving contaminated steroid injections resulted in 64 deaths, receiving a lot of press and …

Two-component histidine phosphotransfer protein Ypd1 is not essential for viability in Candida albicans

J Mavrianos, C Desai, N Chauhan - Eukaryotic cell, 2014 - Am Soc Microbiol
Prokaryotes and lower eukaryotes, such as yeasts, utilize two-component signal
transduction pathways to adapt cells to environmental stress and to regulate the expression …

Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans

S Hameed, Z Fatima - International journal of microbiology, 2013 - Wiley Online Library
Continuous deployment of antifungals in treating infections caused by dimorphic
opportunistic pathogen Candida albicans has led to the emergence of drug resistance …

The two‐component response regulator Skn7 belongs to a network of transcription factors regulating morphogenesis in Candida albicans and independently limits …

V Basso, S Znaidi, V Lagage, V Cabral… - Molecular …, 2017 - Wiley Online Library
Skn7 is a conserved fungal heat shock factor‐type transcriptional regulator. It participates in
maintaining cell wall integrity and regulates the osmotic/oxidative stress response (OSR) in …