The integrated brain network that controls respiration
F Krohn, M Novello, RS van der Giessen, CI De Zeeuw… - Elife, 2023 - elifesciences.org
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …
Neural control of breathing and CO2 homeostasis
PG Guyenet, DA Bayliss - Neuron, 2015 - cell.com
Recent advances have clarified how the brain detects CO 2 to regulate breathing (central
respiratory chemoreception). These mechanisms are reviewed and their significance is …
respiratory chemoreception). These mechanisms are reviewed and their significance is …
[HTML][HTML] Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding
Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …
associated with therapeutic and recreational opioid use. Within the United States, the rate of …
[HTML][HTML] Parabrachial tachykinin1-expressing neurons involved in state-dependent breathing control
JW Arthurs, AJ Bowen, RD Palmiter… - Nature …, 2023 - nature.com
Breathing is regulated automatically by neural circuits in the medulla to maintain
homeostasis, but breathing is also modified by behavior and emotion. Mice have rapid …
homeostasis, but breathing is also modified by behavior and emotion. Mice have rapid …
μ opioid receptor activation hyperpolarizes respiratory‐controlling Kölliker–Fuse neurons and suppresses post‐inspiratory drive
Key points In addition to reductions in respiratory rate, opioids also cause aspiration and
difficulty swallowing, indicating impairment of the upper airways. The Kölliker–Fuse (KF) …
difficulty swallowing, indicating impairment of the upper airways. The Kölliker–Fuse (KF) …
Sleep disturbance as a therapeutic target to improve opioid use disorder treatment.
Sleep health is an important factor across several physical and mental health disorders, and
a growing scientific consensus has identified sleep as a critical component of opioid use …
a growing scientific consensus has identified sleep as a critical component of opioid use …
Proton detection and breathing regulation by the retrotrapezoid nucleus
PG Guyenet, DA Bayliss, RL Stornetta… - The Journal of …, 2016 - Wiley Online Library
We discuss recent evidence which suggests that the principal central respiratory
chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that RTN neurons …
chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that RTN neurons …
Defining the rhythmogenic elements of mammalian breathing
JM Ramirez, N Baertsch - Physiology, 2018 - journals.physiology.org
Breathing's remarkable ability to adapt to changes in metabolic, environmental, and
behavioral demands stems from a complex integration of its rhythm-generating network …
behavioral demands stems from a complex integration of its rhythm-generating network …
Neural circuitry underlying waking up to hypercapnia
Obstructive sleep apnea is a sleep and breathing disorder, in which, patients suffer from
cycles of atonia of airway dilator muscles during sleep, resulting in airway collapse, followed …
cycles of atonia of airway dilator muscles during sleep, resulting in airway collapse, followed …
Kölliker-Fuse/Parabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression
SE Saunders, ES Levitt - Respiratory Physiology & Neurobiology, 2020 - Elsevier
Overdoses caused by the opioid agonist fentanyl have increased exponentially in recent
years. Identifying mechanisms to counter progression to fatal respiratory apnea during …
years. Identifying mechanisms to counter progression to fatal respiratory apnea during …