The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

Tooth agenesis (TA) is one of the most common developmental anomalies that affects the
number of teeth. An extensive analysis of publicly accessible databases revealed 15 …

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Oligodontia is the congenital absence of six or more teeth and comprises the more severe
forms of tooth agenesis. Many genes have been implicated in the etiology of tooth agenesis …

Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the
WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell …

Tooth number abnormality is one of the most common dental developmental diseases,
which includes both tooth agenesis and supernumerary teeth. Tooth development is …

Autism spectrum disorder (ASD) represents a set of complex neurodevelopmental disorders
with large degrees of heritability and heterogeneity. We sequenced 136 microcephaly or …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …