The placenta is a unique organ system that functionally combines both maternal and fetal
cell types with distinct lineage origins. Normal placentation is critical for developmental …

Enhancers are cis-regulatory elements that can stimulate gene expression from distance,
and drive precise spatiotemporal gene expression profiles during development. Functional …

Aged bone marrow mesenchymal stem cells (BMSCs) exhibit aberrant self-renewal and
lineage specification, which contribute to imbalanced bone-fat and progressive bone loss. In …

Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that
give rise to three essential lineages: the trophectoderm, the epiblast and the primitive …

The extravillous trophoblast cell lineage is a key feature of placentation and successful
pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell …

Background Angiogenesis plays an important role in the progress of glioma. RNA-binding
proteins (RBPs) and circular RNAs (circRNAs), dysregulated in various tumors, have been …

The placenta is an essential organ that supports the growth and development of the fetus
during pregnancy. However, cell type-specific enhancers and transcription factors (TFs), and …

Multiple placental pathologies are associated with failures in trophoblast differentiation, yet
the underlying transcriptional regulation is poorly understood. Here, we discovered msh …

The effective proliferation and differentiation of trophoblast stem cells (TSCs) is
indispensable for the development of the placenta, which is the key to maintaining normal …

The hallmarks of stem cells, such as proliferation, self-renewal, development, differentiation,
and regeneration, are critical to maintain stem cell identity which is sustained by genetic and …