Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum
membrane and are responsible for the release of Ca2+ from intracellular stores during …

Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

The ryanodine receptors (RyRs) are a family of Ca2+ release channels found on
intracellular Ca2+ storage/release organelles. The RyR channels are ubiquitously …

Subcellular localization of nitric oxide (NO) synthases with effector molecules is an important
regulatory mechanism for NO signalling. In the heart, NO inhibits L-type Ca2+ channels but …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Regulation of intracellular calcium (Ca 2+) is critical in all cell types. The ryanodine receptor
(RyR), an intracellular Ca 2+ release channel located on the sarco/endoplasmic reticulum …

The cardiac ryanodine receptor (RyR) is the sarcoplasmic reticulum (SR) Ca-release
channel which is centrally involved in the myocyte excitation–contraction (E–C) coupling …

The ability to bind immunosuppressive drugs such as cyclosporin and FK506 defines the
immunophilin family of proteins, and the FK506-binding proteins form the FKBP subfamily of …

There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR)
membrane in cardiac myocytes. The relationship between channel structure, associated …