Oral squamous cell carcinomas: state of the field and emerging directions

Y Tan, Z Wang, M Xu, B Li, Z Huang, S Qin… - International journal of …, 2023 - nature.com
Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

The rediscovery of platinum-based cancer therapy

S Rottenberg, C Disler, P Perego - Nature Reviews Cancer, 2021 - nature.com
Platinum (Pt) compounds entered the clinic as anticancer agents when cisplatin was
approved in 1978. More than 40 years later, even in the era of precision medicine and …

NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer

AR Özeş, DF Miller, ON Özeş, F Fang, Y Liu, D Matei… - Oncogene, 2016 - nature.com
The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA
(lncRNA) HOTAIR (HOX transcript antisense RNA) have diverse functional roles in cancer …

Precision medicine in head and neck cancer

O Kaidar-Person, Z Gil, S Billan - Drug Resistance Updates, 2018 - Elsevier
Head and Neck cancer is among the most common cancers worldwide, with a high
prevalence in south East Asia, Brazil and central Europe. Head and Neck Squamous cell …

Epigenetic modifications and head and neck cancer: implications for tumor progression and resistance to therapy

RM Castilho, CH Squarize, LO Almeida - International journal of …, 2017 - mdpi.com
Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

Epigenetic modifications in head and neck cancer

J Gaździcka, K Gołąbek, JK Strzelczyk… - Biochemical …, 2020 - Springer
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human
malignancy in the world, with high mortality and poor prognosis for patients. Among the risk …

Targeting the DNA Damage Response in OSCC with TP53 Mutations

A Lindemann, H Takahashi, AA Patel… - Journal of dental …, 2018 - journals.sagepub.com
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer worldwide
and in the United States. OSCC remains a major cause of morbidity and mortality in patients …

Effect of regulatory cell death on the occurrence and development of head and neck squamous cell carcinoma

Y Xue, X Jiang, J Wang, Y Zong, Z Yuan, S Miao… - Biomarker …, 2023 - Springer
Head and neck cancer is a malignant tumour with a high mortality rate characterized by late
diagnosis, high recurrence and metastasis rates, and poor prognosis. Head and neck …

Cell death in head and neck cancer pathogenesis and treatment

M Raudenská, J Balvan, M Masařík - Cell Death & Disease, 2021 - nature.com
Many cancer therapies aim to trigger apoptosis in cancer cells. Nevertheless, the presence
of oncogenic alterations in these cells and distorted composition of tumour …

Cancer stem cells in head and neck squamous cell carcinoma: identification, characterization and clinical implications

C Peitzsch, J Nathansen, SI Schniewind, F Schwarz… - Cancers, 2019 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed
cancer worldwide. Despite advances in the treatment management, locally advanced …