In vitro models for immunogenicity prediction of therapeutic proteins
F Groell, O Jordan, G Borchard - European Journal of Pharmaceutics and …, 2018 - Elsevier
Immunogenicity assessment of therapeutic proteins is routinely performed through various
techniques during the drug development process:(i) in silico to design the least …
techniques during the drug development process:(i) in silico to design the least …
Developability considerations for bispecific and multispecific antibodies
Bispecific antibodies (bsAb) and multispecific antibodies (msAb) encompass a diverse
variety of formats that can concurrently bind multiple epitopes, unlocking mechanisms to …
variety of formats that can concurrently bind multiple epitopes, unlocking mechanisms to …
Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide–MHC complexes
Measurements of thermal stability by circular dichroism (CD) spectroscopy have been widely
used to assess the binding of peptides to MHC proteins, particularly within the structural …
used to assess the binding of peptides to MHC proteins, particularly within the structural …
CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity
P Baumgaertner, J Schmidt, CM Costa-Nunes… - Frontiers in …, 2022 - frontiersin.org
Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor
(TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated …
(TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated …
The dendritic cell major histocompatibility complex II (MHC II) peptidome derives from a variety of processing pathways and includes peptides with a broad spectrum of …
The repertoire of peptides displayed in vivo by MHC II molecules derives from a wide
spectrum of proteins produced by different cell types. Although intracellular endosomal …
spectrum of proteins produced by different cell types. Although intracellular endosomal …
Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide
L Yin, P Trenh, A Guce, M Wieczorek, S Lange… - Journal of Biological …, 2014 - ASBMB
HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …
presentation by a mechanism that remains unclear and controversial. Here, we investigated …
HLA-DO Modulates the Diversity of the MHC-II Self-peptidome*[S]
PP Nanaware, MM Jurewicz, JD Leszyk… - Molecular & Cellular …, 2019 - ASBMB
Presentation of antigenic peptides on MHC-II molecules is essential for tolerance to self and
for initiation of immune responses against foreign antigens. DO (HLA-DO in humans, H2-O …
for initiation of immune responses against foreign antigens. DO (HLA-DO in humans, H2-O …
Evaluating the role of HLA-DM in MHC class II–peptide association reactions
Ag presentation by MHC class II (MHC II) molecules to CD4+ T cells plays a key role in the
regulation of the adaptive immune response. Loading of antigenic peptides onto MHC II is …
regulation of the adaptive immune response. Loading of antigenic peptides onto MHC II is …
Impact of HLA-DR antigen binding cleft rigidity on T cell recognition
The interaction between T cell receptor (TCR) and peptide (p)-Human Leukocyte Antigen
(HLA) complexes is the critical first step in determining T cell responses. X-ray …
(HLA) complexes is the critical first step in determining T cell responses. X-ray …
A missing switch in peptide exchange for MHC class II molecules
C Freund, T Höfer - Frontiers in immunology, 2019 - frontiersin.org
Antigen processing and loading of peptides onto MHC class II molecules is a multistep
process that involves vesicular transport of the MHCII molecules along the secretory …
process that involves vesicular transport of the MHCII molecules along the secretory …